解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The nontoxic C fragment of tetanus toxin (TC) can transport other proteins from the circulation to central nervous system (CNS) motor neurons. Increased levels of CuZn superoxide dismutase (SOD) are protective in experimental models of stroke and Parkinson's disease, whereas mutations in SOD can cause motor neuron dis...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6490
更新日期:1997-06-01 00:00:00
abstract::Physiological/anatomical studies of rat frontal cortex in vitro have distinguished subpopulations of gamma-aminobutyric acid (GABA)-expressing inhibitory interneurons defined by expression of the calcium-binding proteins, parvalbumin (PV) and calbindin (CA). Using a novel 2DG/immunostaining technique to double-label h...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6426
更新日期:1997-05-01 00:00:00
abstract::Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6468
更新日期:1997-05-01 00:00:00
abstract::Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether binding to membrane proteins is sufficient for ganglioside-mediate...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6459
更新日期:1997-05-01 00:00:00
abstract::Experimental tumors of the central nervous system were investigated with antibodies to quinolinate to assess the cellular distribution of this endogenous neurotoxin. In advanced F98 and RG-2 glioblastomas and E367 neuroblastomas in the striatum of rats, variable numbers of quinolinate immunoreactive cells were observe...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.6365
更新日期:1997-04-01 00:00:00
abstract::Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6427
更新日期:1997-04-01 00:00:00
abstract::For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.6386
更新日期:1997-03-01 00:00:00
abstract::Adeno-associated virus (AAV) vectors are derived from a nonpathogenic and defective human parvovirus. Although currently unable to display the integration specificity featured by its wild-type parent, the recombinant AAV (rAAV) system has continued to attract enormous interest primarily due to its unique features such...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.6396
更新日期:1997-03-01 00:00:00
abstract::The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces Parkinsonism, is mediated by its metabolite 1-methyl-4-phenylpyridinium ion (MPP+). When injected into the striatum MPP+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6416
更新日期:1997-03-01 00:00:00
abstract::Nitric oxide may be a key mediator of excitotoxic neuronal injury in the central nervous system. In the present experiments we found that S-methylthiocitrulline, a relatively selective neuronal nitric oxide synthase (NOS) inhibitor, produced significant neuroprotection against striatal lesions produced by malonate, an...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.6406
更新日期:1997-02-01 00:00:00
abstract::Rats were given unilateral 6-hydroxydopamine lesions and tested 4 weeks later for rotational behavior elicited by either systemic or intranigral injections of dopamine agonists. Subsequently, transplants of fetal (E14) ventral mesencephalic (VM) or cortical tissue were implanted into the lesioned substantia nigra and ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.6359
更新日期:1997-01-01 00:00:00
abstract::Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.6345
更新日期:1997-01-01 00:00:00
abstract::Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0198
更新日期:1996-12-01 00:00:00
abstract::In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions. These reductions likely follow regional synaptic loss or d...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.0180
更新日期:1996-11-01 00:00:00
abstract::Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0190
更新日期:1996-11-01 00:00:00
abstract::Microglia express cytokines, major histocompatibility (MHC) loci, and several other immunologically important constituents. The aim of this study was to detect immunological responses of microglial cells following allogeneic dopaminergic transplantation using active and adoptive immunizations. Adult inbred Fisher 344 ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0151
更新日期:1996-10-01 00:00:00
abstract::The neuronal basis for neurological deficits in infantile hydrocephalus is poorly understood. Changes in the dendritic architecture of pyramidal cells of the auditory cortex have been measured at 21 days after birth in H-Tx rats. Tissue was prepared by the rapid Golgi method from hydrocephalic and control litter-mates...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0161
更新日期:1996-10-01 00:00:00
abstract::The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0169
更新日期:1996-10-01 00:00:00
abstract::Grafts of embryonic ventral mesencephalic tissue placed in the striatum of 6-hydroxydopamine-lesioned rats survive, and make and receive connections to and from the host brain. The dopaminergic neurons of the graft can grow processes into the host brain, and thereby alleviate many of the behavioral deficits of this fo...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.0141
更新日期:1996-09-01 00:00:00
abstract::To test the hypothesis that prepubertal exposure of LHRH neurons to a source of catecholamines and neuropeptides accelerates the onset of puberty, we examined the effects of autologous adrenal transplantation into the base of the third ventricle of the brain in juvenile female rhesus monkeys at 11-13 months of age. Th...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0127
更新日期:1996-08-01 00:00:00
abstract::Poor survival of embryonic dopamine neurons is a primary problem limiting the value of neurotransplantation for Parkinson's disease. Several neurotrophic factors have been shown to promote dopamine neuron survival when used individually in culture. We have found that two peptides, insulin-like growth factor-I (IGF-I) ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0115
更新日期:1996-07-01 00:00:00
abstract::Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0101
更新日期:1996-06-01 00:00:00
abstract::In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0088
更新日期:1996-05-01 00:00:00
abstract::Destruction of the entorhinal cortex (EC) triggers a number of cellular and molecular responses in the denervated hippocampus and dentate gyrus. The signals that trigger these changes are not known but could include physiological events that occur during the production of the injury or during the early postlesion peri...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0082
更新日期:1996-05-01 00:00:00
abstract::Neurons lesioned in the peripheral nervous system (PNS) generally regenerate and survive, while neurons lesioned in the central nervous system (CNS) do not regenerate and often die. Investigators have traditionally compared the neuronal responses to PNS and CNS lesions in two separate populations of neurons. In this s...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0060
更新日期:1996-04-01 00:00:00
abstract::These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0070
更新日期:1996-04-01 00:00:00
abstract::Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0042
更新日期:1996-03-01 00:00:00
abstract::Dorsal root ganglia (DRG) neuronopathy was induced in rats by chronic treatment (2 mg/kg twice a week for nine injections) with the antineoplastic drug cisplatin. Morphological alterations and changes in peptide [calcitonin gene-related peptide (CGRP), substance P, galanin (Gal), and somatostatin] concentration were s...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0050
更新日期:1996-03-01 00:00:00
abstract::This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0024
更新日期:1996-02-01 00:00:00
abstract::Propentofylline is a xanthine derivative that has been known to protec t neurons against ischemia-induced damage. To assess its neuroprotective mechanisms, we examined the effect of propentofylline on microglial proliferation that is thought to play an important role in neuronal damage. We determined the proliferation...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0035
更新日期:1996-02-01 00:00:00
abstract::The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0004
更新日期:1996-01-01 00:00:00
abstract::Hippocampal transplants were examined for the expression of three specific immediate early gene encoded proteins in order to establish if grafted immature tissue maintains the basic molecular program necessary for gene transcription after grafting to excitotoxic (ibotenic acid-induced) lesions in adult host rat brains...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1097
更新日期:1995-12-01 00:00:00
abstract::This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1079
更新日期:1995-11-01 00:00:00
abstract::The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1062
更新日期:1995-09-01 00:00:00
abstract::Inherited neurological diseases in animals are of interest to a wide range of scientific disciplines, particularly because such animals may be suited as genetic animal models for respective human disorders. Because the pig has a number of anatomic and physiologic features similar to those of human beings, this species...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1050
更新日期:1995-08-01 00:00:00
abstract::With the use of four independent cell markers and Brd-U birthdating we have charted the earliest stages of neuronal differentiation and migration in the developing rat central nervous system, including the cortex, spinal cord, and retina. One of the markers, the monoclonal antibody 2G12, labeled a large subpopulation ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1031
更新日期:1995-07-01 00:00:00
abstract::Although aluminum (Al) contributes to a variety of cognitive dysfunctions and mental diseases, the underlying mechanisms of Al interactions with the nervous system are still unknown. We have studied the action of Al on synaptic transmission and long-term potentiation (LTP) by performing electrophysiological recordings...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1038
更新日期:1995-07-01 00:00:00
abstract::We have previously demonstrated that systemic administration of testosterone propionate (TP) to adult hamsters accelerates the rate of facial nerve regeneration following crush axotomy of the facial nerve at its exit from the stylomastoid foramen. In this study, we utilized flutamide, a potent nonsteroidal antiandroge...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1016
更新日期:1995-06-01 00:00:00
abstract::Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1028
更新日期:1995-06-01 00:00:00
abstract::We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1995.1025
更新日期:1995-06-01 00:00:00